Sevelamer Hydrochloride is used to treat high phosphate levels in patients with kidney disease․
The dosage is based on the patient’s phosphorus level and should be taken with meals․
Uses and Dosage
Sevelamer Hydrochloride is used to lower phosphate levels in patients with chronic kidney disease․
The typical starting dose for adults is 2․4 grams, three times daily with meals․ The dosage can be adjusted based on serum phosphorus levels․ It is important to swallow the tablets whole and not crush or chew them․
Side Effects and Management
Common side effects of Sevelamer Hydrochloride include nausea, vomiting, diarrhea, or constipation․
To manage nausea, take the medication with meals․ For constipation, adequate fluid intake is recommended․ Serious side effects such as severe stomach pain or difficulty swallowing should be reported to a healthcare provider immediately․
Differences in Chemical Structure
Sevelamer Hydrochloride and Sevelamer Carbonate differ in their chemical structures․
Sevelamer Hydrochloride is in hydrochloride salt form, while Sevelamer Carbonate is a carbonate salt․ These structural variances impact how they interact with phosphate in the body․
Efficacy and Safety Comparison
The efficacy and safety of Sevelamer Hydrochloride and Sevelamer Carbonate are comparable․
Both medications effectively lower phosphate levels in patients with chronic kidney disease․ Safety profiles include gastrointestinal side effects like nausea and vomiting, with rare cases of severe allergic reactions․ Discuss with your healthcare provider to determine which medication is best for you․
Binding Properties
Sevelamer Hydrochloride works by binding to phosphate in the GI tract, preventing its absorption․
This binding reduces phosphate levels in the blood, helping to manage hyperphosphatemia in patients with chronic kidney disease․ By lowering phosphate absorption, it helps prevent complications associated with elevated phosphorus levels․
Active Ingredients in Renagel Tablets
The active ingredient in Renagel Tablets is Sevelamer Hydrochloride․
This compound binds to phosphate in the gut, reducing its absorption and aiding in the management of elevated phosphate levels in patients with chronic kidney disease․
Inactive Ingredients
The inactive ingredients in Renagel Tablets may include colloidal silicon dioxide, crospovidone, magnesium stearate, and microcrystalline cellulose․
These inactive components play a role in the formulation and physical properties of the tablet but do not have an active pharmacological effect․
Phosphate Level Regulation
Sevelamer Hydrochloride plays a crucial role in regulating phosphate levels in patients with chronic kidney disease․
By binding to phosphate in the gut, it reduces the amount absorbed into the bloodstream, helping to maintain optimal phosphate balance and prevent complications associated with hyperphosphatemia․